| Characteristic | Description |
|---|---|
| Active Ingredient | Sildenafil Citrate |
| Standard Dosage | 100 mg |
| Route of Administration | Oral |
| Onset of Action | 30 to 60 minutes |
| Duration of Effect | Up to 4 hours |
| Learn More About Aurogra | |
Chemical Structure
The active component in Aurogra is Sildenafil Citrate. It belongs to the phosphodiesterase type 5 (PDE5) inhibitors. This class of drugs modulates cyclic guanosine monophosphate (cGMP) levels. The chemical formula for Sildenafil is C22H30N6O4S. Its molecular architecture facilitates the blocking of the PDE5 enzyme. This blockade amplifies the relaxation of smooth muscle in the corpus cavernosum.
Crystal structures depict a tetragonal arrangement. Bond angles optimize interaction with the enzyme’s active site. The citrate moiety enhances solubility, crucial for oral bioavailability. The unique structure underpins its efficacy in treating erectile dysfunction.
Off-Label Uses
Aurogra 100 mg is primarily utilized for erectile dysfunction. However, its pharmacological properties extend beyond this. Off-label, it aids in treating pulmonary arterial hypertension (PAH). It relaxes blood vessels, decreasing pulmonary blood pressure.
Researchers have explored its use in treating Raynaud’s phenomenon. Its vasodilatory effects offer symptomatic relief. Another potential area is altitude sickness, where it improves oxygenation.
Clinical trials (source) investigate novel applications. Outcomes are preliminary, emphasizing the need for caution. Off-label prescribing requires thorough clinical justification.
Who Can and Cannot Take Aurogra
Aurogra suits adults with erectile dysfunction. Its use requires physician oversight. Individuals with cardiovascular disorders must be cautious. The drug can exacerbate certain heart conditions.
Patients with severe hepatic or renal impairment should avoid it. It could aggravate these underlying issues. Those with hypersensitivity to sildenafil or its constituents should abstain.
Pediatric populations and women are not typical candidates. The FDA does not endorse such use. Assess each case individually, with informed professional advice.
Aurogra Interactions
Aurogra interacts with nitrates used in angina. This combination causes a severe drop in blood pressure. Alpha-blockers can similarly interact, requiring dose adjustments.
Antihypertensives might amplify hypotensive effects. Avoid concurrent intake with potent CYP3A4 inhibitors. Drugs like ketoconazole or itraconazole intensify its action.
| Interaction | Effect |
|---|---|
| Nitrates | Severe hypotension |
| CYP3A4 Inhibitors | Increased plasma levels |
Toxicity
Sildenafil 100 mg has a favorable safety profile. Overdosage results in adverse effects. Symptoms include headache, dizziness, and indigestion.
Severe toxicity manifests as vision disturbances. High doses exacerbate cardiovascular risk. Manage overdose with symptomatic treatment.
Animal studies provide insight into its LD50. Human data remain limited. Vigilance in dosing minimizes toxicity risks.
Is Non-Prescription Aurogra Available?
Aurogra 100 mg requires a prescription. Regulations mandate this to ensure safe use. Off-label acquisitions carry legal and health risks.
Some regions impose stricter controls. Regulatory agencies scrutinize non-prescription availability. This oversight protects public health.
Consult healthcare professionals for proper guidance. Ensuring legitimate sourcing prevents adverse outcomes. Always adhere to prescribed regimens.